FAQ (Frequently Asked Questions) on
Membrane Lipid Replacement
Q. What is Membrane Lipid Replacement?
A. Membrane Lipid Replacement is the use of oral membrane phospholipids
to replace damaged cellular membrane lipids and restore cellular
membrane properties and function.
Q. What is the clinical trial test product for
Membrane Lipid Replacement?
A. Phospholipids, such as those found in The Trial phospholipid
supplement, contain membrane glycerolphospholipids. This special class
of phospholipids is important in maintaining cellular health and
function and repairing cellular membranes.
Q. Why are the phospholipids in the Trial phospholipid
supplement so important in repairing and replacing damaged cell
A. Cellular membrane phospholipids become oxidized and stiff as we age
or as we become sick with diseases like Fibromyalgia, much like
oxidation causes rust and damages metal surfaces. The Trial supplement
can replace these oxidized membrane lipids with healthy vital, undamaged
phospholipids, which can then restore lost membrane function. That is
why it is called ‘Membrane Lipid Replacement.’ Some vitamins and
antioxidants can help prevent cell membrane oxidative damage, but they
do not repair damaged cellular membranes.
Q. What else is in the Trial phospholipid supplement
besides membrane phospholipids?
A. The Trial phospholipid supplement also contains some trace elements
like sodium borate and some filers, such as vegetable juice (beet) for
color, citric acid for taste and traces of other natural flavors and
plant xylitol, as a binder to hold the wafers together. An important
minor ingredient is plant fructooligosaccharides (to protect the
phospholipids from damage) and pantethine, a coenzyme A precursor.
Q. Does The Trial phospholipid supplement contain any
soy proteins, milk products, egg products, fish, or crustacean shellfish
products, tree nuts, peanuts, yeast, wheat, gluten, rice, beef or pork
A. No. It also does not contain any stimulants, alkaloids,
preservatives, hormones (or hormone-like compounds) or non-food material
whatsoever. It does not contain any common allergens, such as wheat,
dairy, soy proteins, animal by-products, or artificial flavorings,
digestible plastics, caffeine or sugar.
Q. How is The Trial phospholipid supplement different
from other supplements that claim to fight fatigue and pain?
A. The Trial phospholipid supplement is an ingredient mixture that has
been proven in clinical trials to significantly reduce fatigue. Some
manufacturers create the illusion of efficacy by discussing aspects of
the energy producing process or the oxidation and/or transport of
pre-energy compounds like sugars and/or fats. However, the Trial
phospholipid supplement is the only supplement to actually be evaluated
successfully in clinical trials for reducing fatigue and increasing
cellular energy function. In preliminary studies the Trial phospholipid
supplement was found to reduce the type of pain found in Fibromyalgia.
This study was conceived to provide additional evidence for these
Q. How can The Trial phospholipid supplement improve
A. The ingredients in the Trial phospholipid supplement improve membrane
health and all the functions of cellular membranes. This includes the
outer or plasma membrane and all of the membranes of compartments within
the cell, such as mitochondria (the energy producing compartments inside
our cells). Since the aging process and the development of chronic
diseases are both accompanied by oxidation and deterioration of
membranes, especially mitochondrial membranes, it is clear that
replacement of the damaged membrane components could slow or change this
direction and restore lost function.
Q. What are the anti-aging benefits of the Trial
A. It has been shown in clinical (and pre-clinical) trials that membrane
phospholipids can maximize a person’s energy. It was also reported to
improve membrane stability and electrical potential, and these are
essential for cellular metabolism. As a result of regular use, a person
will get more out of the food they eat and the nutrients and vitamins
(such as found in multi-vitamin supplements) they consume due to the
carrier properties of The Trial phospholipid supplement that allow
better food and vitamin uptake.
Q. How does the Trial phospholipid supplement
counteract cellular damage from free radicals?
A. Free radicals damage us by reacting with the fats in cellular
membranes (these are called membrane phospholipids) of our cells.
Ingredients, such as the Trial phospholipid supplement, replace damaged,
oxidized membrane phospholipids with healthy, unoxidized phospholipids.
The phospholipids and antioxidants in the Trial phospholipid supplement
can also directly protect against free radical damage.
Q. How does the Trial phospholipid supplement support
my immune function?
A. The Trial phospholipid supplement improves the available energy that
your immune system needs to function. The easiest way to realize this is
the common experience that when you are very tired and run down, it is
easier to become sick. The Trial phospholipid supplement also improves
the ability of your body to produce and replace the cells that make up
your immune system.
Q. How is the Trial phospholipid supplement different
from other supplements that claim to help cellular function?
A. The Trial phospholipid supplement provides the ability to restore
lost membrane function and provides necessary cellular components.
Typically, fresh nutrients can potentially help to mitigate future
cellular damage, but only the Trial phospholipid supplement has been
proven to be able to restore lost membrane function. An example is that
we expect older people to have less energy and fatigue more easily. In
one clinical trial it significantly reduced fatigue and restored the
energy producing ability (called mitochondrial function) in elderly
people to levels typical of healthy 30-year-old adults.
Q. How does The Trial phospholipid supplement improve
fatigue caused by exercise?
A. By improving mitochondrial function and reducing the damage done to
the membranes from exercise and the production of free radicals, the
Trial phospholipid supplement will improve fatigue and speed recovery
from exercise fatigue.
Q. What can I expect when I take the Trial
phospholipid supplement? How long until the effect takes place?
A. The Trial phospholipid supplement works by supplying and saturating
gut mucosal membranes with membrane phospholipids and small lipid
globules that contain membrane phospholipids. Some of the phospholipids
will then be picked up by carrier molecules and cells and transported
throughout the body. This process begins immediately and gradually
increases, but for fatigue, changes occur within one to four weeks, and
individuals begin to feel the improvement in their ability to do more
and fatigue less easily. For other symptoms the changes occur more
quickly, and this study will be studying the times required to change
Fibromyalgia symptom severity.
Q. Should the Trial phospholipid supplement be taken
A. It is best to take the Trial phospholipid supplement 20-30 minutes
before breakfast and again 20-30 minutes before dinner. However, it can
also be taken along with light meals or taken alone without food. The
reason for this is that the fat in the meal contains phospholipids that
can interfere or compete with the phospholipids in the Trial
phospholipid supplement. It should also be taken 20-30 minutes before
meal replacement products that contain lecithin or other lipids for the
Q. Why is improvement in mitochondrial function so
important for optimizing my health?
A. Mitochondria do many things–one of which is to produce cellular
energy necessary for cellular metabolism and the processing of food.
Mitochondria are also essential for producing energy used by nerve cells
to maintain nerve cell membrane function. One possible reason why
Fibromyalgia patients have so much nerve and pain problems is that their
peripheral nerves (such as the peripheral pain-signaling nerve cells)
may have lost the electrical balance necessary to prevent spontaneous
Q. How does the Trial phospholipid supplement work in
combination with other supplements, such as vitamins, minerals, herbs
A. The Trial phospholipid supplement will make other nutrients more
effective and better utilized, because the membrane phospholipids in The
Trial phospholipid supplement have been proven to improve membrane
potential and production of high-energy molecules necessary for
transport and uptake. Membrane potential refers to the electrical
activity of a membrane that drives metabolism. This is a necessary
process that provides the energy to metabolize foods, and it also helps
with other functions inside cells.
Q. How does the Trial phospholipid supplement improve
A. The membrane phospholipids in the Trial phospholipid supplement are
particularly beneficial because, in addition to improving the health of
the cell membranes that line the digestive tract, they help to support
healthy microflora (friendly bacteria) in the gut.
Q. How safe is the Trial phospholipid supplement?
A. The Trial phospholipid supplement is exceptionally safe. It is
considered safe by the FDA (Food and Drug Agency). It has no maximum
dose requirement, and it was shown to be completely safe in animals and
Q. What are the precautions when taking the Trial
A. There are none.
Q. How can The Trial phospholipid supplement improve
my quality of life?
A. By improving nutrition, energy, anti-oxidant protection and cellular
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